AIMC Topic: Aromatase Inhibitors

Clear Filters Showing 1 to 10 of 11 articles

Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.

BMC cancer May 8, 2025
BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized controlled trials involving the...
Humans Benzimidazoles Receptors, Estrogen Purines Receptors, Progesterone Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Network Meta-Analysis as Topic Aminopyridines Randomized Controlled Trials as Topic Progression-Free Survival Receptor, ErbB-2 Aromatase Inhibitors Protein Kinase Inhibitors Female Breast Neoplasms Antineoplastic Combined Chemotherapy Protocols Treatment Outcome
View on PubMed DOI

Comparing Machine Learning Models for Aromatase (P450 19A1).

Environmental science & technology Nov 19, 2020
Aromatase, or cytochrome P450 19A1, catalyzes the aromatization of androgens to estrogens within the body. Changes in the activity of this enzyme can produce hormonal imbalances that can be detrimental to sexual and skeletal development. Inhibition o...
Prospective Studies Machine Learning Bayes Theorem Aromatase Inhibitors Aromatase Androgens
View on PubMed DOI

Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase Inhibitors.

Hormone research in paediatrics Feb 28, 2019
BACKGROUND: The combination of growth hormone (GH) and aromatase inhibitors (AI) improves linear growth in severely short adolescent boys; however, the effects of this intervention on quality of life (QoL) are unknown. This study assesses whether GH,...
Adolescent Humans Human Growth Hormone Male Growth Disorders Quality of Life Follow-Up Studies Surveys and Questionnaires Aromatase Inhibitors
View on PubMed DOI

Comparison of Changes in the Lipid Profiles of Eastern Chinese Postmenopausal Women With Early-Stage Breast Cancer Treated With Different Aromatase Inhibitors: A Retrospective Study.

Clinical pharmacology in drug development Dec 29, 2017
Cardiovascular morbidity is closely associated with serum lipid level. We aimed to investigate the effects of different aromatase inhibitors, including letrozole, anastrozole, and exemestane, on the lipid profile of eastern Chinese breast cancer pati...
Middle Aged Letrozole China Lipids Postmenopause Humans Lipid Metabolism Aromatase Inhibitors Retrospective Studies Asian People Anastrozole Female Androstadienes Aged Breast Neoplasms
View on PubMed DOI

Optimal adjuvant endocrine treatment of ER+/HER2+ breast cancer patients by age at diagnosis: A population-based cohort study.

European journal of cancer (Oxford, England : 1990) Dec 21, 2017
BACKGROUND: Prior randomised controlled trials on adjuvant hormonal therapy included HER2 patients; however, a differential effect of aromatase inhibitors (AIs) versus tamoxifen (TAM) may have been missed in ER+/HER2+ patients that comprise 7-15% of ...
Breast Neoplasms Middle Aged Cohort Studies Disease-Free Survival Netherlands Age of Onset Receptor, ErbB-2 Proportional Hazards Models Aromatase Inhibitors Kaplan-Meier Estimate Humans Female Aged Adult Receptors, Estrogen Antineoplastic Agents, Hormonal Chemotherapy, Adjuvant Tamoxifen
View on PubMed DOI

Cognitive sequelae of endocrine therapy in women treated for breast cancer: a meta-analysis.

Breast cancer research and treatment Dec 20, 2017
PURPOSE: Evidence suggests anti-estrogen endocrine therapy (ET) is associated with adverse cognitive effects; however, findings are based on small samples and vary in the cognitive abilities affected. We conducted a meta-analysis to quantitatively sy...
Cognition Disorders Aromatase Inhibitors Antineoplastic Agents, Hormonal Neuropsychological Tests Memory Verbal Learning Humans Female Breast Neoplasms Cross-Sectional Studies Cognition
View on PubMed DOI

Genomic risk prediction of aromatase inhibitor-related arthralgia in patients with breast cancer using a novel machine-learning algorithm.

Cancer medicine Nov 23, 2017
Many breast cancer (BC) patients treated with aromatase inhibitors (AIs) develop aromatase inhibitor-related arthralgia (AIA). Candidate gene studies to identify AIA risk are limited in scope. We evaluated the potential of a novel analytic algorithm ...
Case-Control Studies Genomics Genetic Predisposition to Disease Polymorphism, Single Nucleotide Neoplasm Staging Prognosis Female Breast Neoplasms Middle Aged Humans Aromatase Inhibitors Machine Learning Arthralgia Antineoplastic Agents, Hormonal Germ-Line Mutation
View on PubMed DOI

Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Disease Models, Animal bcl-2-Associated X Protein Endometriosis Vascular Endothelial Growth Factor A Triazoles Rats Cell Proliferation Angiogenesis Inhibitors Endometrium Ovarian Follicle Anastrozole Peritoneal Diseases Proto-Oncogene Proteins c-kit Transplantation, Autologous Peritoneum Imatinib Mesylate Nitriles Aromatase Inhibitors Female Animals
View on PubMed DOI

Neoadjuvant endocrine treatment in early breast cancer: An overlooked alternative?

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Nov 23, 2015
During the last decade neoadjuvant endocrine therapy (NET) has moved from being reserved for elderly and frail non-chemotherapy candidates to a primary systemic modality in selected patients with hormone sensitive breast cancer. Neoadjuvant hormonal ...
Neoplasm Invasiveness Randomized Controlled Trials as Topic Neoplasm Staging Receptor, ErbB-2 Aromatase Inhibitors Antineoplastic Agents, Hormonal Mastectomy, Segmental Humans Treatment Outcome Prognosis Neoadjuvant Therapy Female Age Factors Risk Factors Magnetic Resonance Imaging Aged Early Detection of Cancer Adult Breast Neoplasms Middle Aged
View on PubMed DOI

Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure.

Journal of the National Cancer Institute Dec 1, 2017
BACKGROUND: Aromatase inhibitors (AIs) are given as adjuvant therapy for hormone receptor-positive breast cancer in postmenopausal women, also to those with chemotherapy-induced ovarian function failure. The current analysis reports on endocrine data...
Chemotherapy, Adjuvant Humans Clinical Trials, Phase III as Topic Randomized Controlled Trials as Topic Breast Neoplasms Prognosis Ovarian Diseases Aromatase Inhibitors Middle Aged Female Ovary Anastrozole Case-Control Studies Tamoxifen Adult Antineoplastic Agents, Hormonal Estradiol Recovery of Function
View on PubMed DOI
Popular Topics
Recent Journals