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bcl-2-Associated X Protein

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Paeonol impacts ovarian cancer cell proliferation, migration, invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 38345445
Paeonol (2-hydroxy-4-methoxyphenylacetophenone) is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities and has been proven to have anti-cancer effects. The objective of this study is to investiga...
Acetophenones Apoptosis bcl-2-Associated X Protein Cell Line, Tumor Cell Movement Cell Proliferation Female Humans Ovarian Neoplasms Signal Transduction Transforming Growth Factor beta
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Synthesis and evaluation of a novel nanosized anionic linear globular dendrimer G2-ciprofloxacin conjugate against prostate cancer.

Pakistan journal of pharmaceutical sciences 33867334
Prostate cancer is the second most common cancer in the world and the fifth cause of cancer deaths in men. Ciprofloxacin enables the inhabitation of the development of prostate cancer. In this regard, we plan to improve the anticancer effect of cipro...
Antineoplastic Agents Apoptosis bcl-2-Associated X Protein Cell Line, Tumor Ciprofloxacin Dendrimers Drug Delivery Systems Humans Male Nanostructures Prostatic Neoplasms Proto-Oncogene Proteins c-bcl-2
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences 28137413
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Achyranthes Animals Anti-Inflammatory Agents, Non-Steroidal Apoptosis bcl-2-Associated X Protein bcl-Associated Death Protein bcl-X Protein Cartilage, Articular Caspase 3 Chondrocytes Cyclooxygenase 2 Gene Expression Regulation Inflammation Interleukin-1beta Male Matrix Metalloproteinase 3 Matrix Metalloproteinase 9 NF-kappa B Plant Extracts Plant Roots Primary Cell Culture Proliferating Cell Nuclear Antigen Rats Rats, Sprague-Dawley Saponins Signal Transduction Tumor Suppressor Protein p53
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Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts.

Cell biochemistry and biophysics 27352334
The aim is to study the effects and underlying mechanisms of astragalus polysaccharide (APS) on the peroxide-induced injury in C2C12 myoblasts in vitro. Cell viability in the presence or absence of APS was detected by the methyl thiazolyl tetrazolium...
Animals Apoptosis Astragalus Plant Autophagy bcl-2-Associated X Protein Blotting, Western Caspase 3 Cell Line Cell Survival Cytochromes c Hydrogen Peroxide Mice Microscopy, Electron Microtubule-Associated Proteins Myoblasts Polysaccharides Proto-Oncogene Proteins c-bcl-2 Ribosomal Protein S6 Kinases, 70-kDa Signal Transduction TOR Serine-Threonine Kinases
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[Experimental study on effect of model on hepatic fibrosis with Aralia chinesis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 27071266
Hepatic fibrosis models were induced by CCl4 in rats. To explore vascular endothelial growth factor (VEGF), transforming growth factor-beta1 (TGFβ1) mRNA expression and bcl-2, Bax protein expression levels of intervention and explore the mechanism of...
Animals Apoptosis Aralia bcl-2-Associated X Protein Drugs, Chinese Herbal Hepatic Stellate Cells Humans Liver Cirrhosis Male Proto-Oncogene Proteins c-bcl-2 Rats Rats, Sprague-Dawley Transforming Growth Factor beta1 Vascular Endothelial Growth Factor A
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[Oxidative stress and mitochondrion-related cell apoptosis in human bronchial epithelial 16HBE cells induced by silica dust].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 26887260
OBJECTIVE: To investigate oxidative stress and mitochondria-related cell apoptosis induced by silica dust in human normal bronchial epithelial 16HBE cells.
Apoptosis bcl-2-Associated X Protein Cell Survival Cells, Cultured Dust Epithelial Cells Humans L-Lactate Dehydrogenase Mitochondria Oxidative Stress Proto-Oncogene Proteins c-bcl-2 Reactive Oxygen Species Silicon Dioxide Superoxide Dismutase
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology 26773307
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Anastrozole Angiogenesis Inhibitors Animals Aromatase Inhibitors bcl-2-Associated X Protein Cell Proliferation Disease Models, Animal Endometriosis Endometrium Female Imatinib Mesylate Nitriles Ovarian Follicle Peritoneal Diseases Peritoneum Proto-Oncogene Proteins c-kit Rats Transplantation, Autologous Triazoles Vascular Endothelial Growth Factor A
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