AIMC Topic: bcl-2-Associated X Protein

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Paeonol impacts ovarian cancer cell proliferation, migration, invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Feb 7, 2024
Paeonol (2-hydroxy-4-methoxyphenylacetophenone) is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities and has been proven to have anti-cancer effects. The objective of this study is to investiga...
Ovarian Neoplasms Transforming Growth Factor beta Cell Proliferation Acetophenones Humans bcl-2-Associated X Protein Signal Transduction Female Cell Movement Cell Line, Tumor Apoptosis
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Matrix Metalloproteinase 9 bcl-2-Associated X Protein Chondrocytes Saponins Tumor Suppressor Protein p53 Gene Expression Regulation Proliferating Cell Nuclear Antigen Cyclooxygenase 2 Anti-Inflammatory Agents, Non-Steroidal Plant Roots Interleukin-1beta NF-kappa B Rats, Sprague-Dawley Apoptosis Caspase 3 Plant Extracts Rats Inflammation Signal Transduction Achyranthes Animals bcl-Associated Death Protein Cartilage, Articular Male bcl-X Protein Matrix Metalloproteinase 3 Primary Cell Culture
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Endometriosis Female Vascular Endothelial Growth Factor A Animals Ovarian Follicle Rats Triazoles Endometrium Anastrozole Peritoneum Cell Proliferation Transplantation, Autologous Disease Models, Animal Peritoneal Diseases Imatinib Mesylate Angiogenesis Inhibitors bcl-2-Associated X Protein Proto-Oncogene Proteins c-kit Nitriles Aromatase Inhibitors
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Synthesis and evaluation of a novel nanosized anionic linear globular dendrimer G2-ciprofloxacin conjugate against prostate cancer.

Pakistan journal of pharmaceutical sciences Nov 1, 2020
Prostate cancer is the second most common cancer in the world and the fifth cause of cancer deaths in men. Ciprofloxacin enables the inhabitation of the development of prostate cancer. In this regard, we plan to improve the anticancer effect of cipro...
Prostatic Neoplasms Ciprofloxacin bcl-2-Associated X Protein Nanostructures Dendrimers Antineoplastic Agents Proto-Oncogene Proteins c-bcl-2 Humans Cell Line, Tumor Apoptosis Drug Delivery Systems Male
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Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts.

Cell biochemistry and biophysics Nov 1, 2015
The aim is to study the effects and underlying mechanisms of astragalus polysaccharide (APS) on the peroxide-induced injury in C2C12 myoblasts in vitro. Cell viability in the presence or absence of APS was detected by the methyl thiazolyl tetrazolium...
Microtubule-Associated Proteins Astragalus Plant Cytochromes c Ribosomal Protein S6 Kinases, 70-kDa Polysaccharides Proto-Oncogene Proteins c-bcl-2 Myoblasts Microscopy, Electron Autophagy TOR Serine-Threonine Kinases Hydrogen Peroxide bcl-2-Associated X Protein Mice Signal Transduction Apoptosis Cell Line Animals Cell Survival Caspase 3 Blotting, Western
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[Experimental study on effect of model on hepatic fibrosis with Aralia chinesis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Nov 1, 2015
Hepatic fibrosis models were induced by CCl4 in rats. To explore vascular endothelial growth factor (VEGF), transforming growth factor-beta1 (TGFβ1) mRNA expression and bcl-2, Bax protein expression levels of intervention and explore the mechanism of...
Apoptosis Drugs, Chinese Herbal Transforming Growth Factor beta1 Hepatic Stellate Cells Rats Liver Cirrhosis Rats, Sprague-Dawley bcl-2-Associated X Protein Vascular Endothelial Growth Factor A Proto-Oncogene Proteins c-bcl-2 Aralia Humans Animals Male
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[Oxidative stress and mitochondrion-related cell apoptosis in human bronchial epithelial 16HBE cells induced by silica dust].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases Nov 1, 2015
OBJECTIVE: To investigate oxidative stress and mitochondria-related cell apoptosis induced by silica dust in human normal bronchial epithelial 16HBE cells.
Humans Cells, Cultured Oxidative Stress Superoxide Dismutase Mitochondria Proto-Oncogene Proteins c-bcl-2 L-Lactate Dehydrogenase Epithelial Cells Cell Survival Silicon Dioxide bcl-2-Associated X Protein Dust Apoptosis Reactive Oxygen Species
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