Identification of key gene signatures for predicting chemo-immunotherapy efficacy in extensive-stage small-cell lung cancer using machine learning.

Journal: Lung cancer (Amsterdam, Netherlands)
PMID: 39787635

Abstract

OBJECTIVES: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through comprehensive gene expression analysis using machine learning (ML).

Authors

  • Daichi Fujimoto
    Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
  • Ryota Shibaki
    Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
  • Keiichi Kimura
    AOI Biosciences Inc., Tokyo, Japan.
  • Koji Haratani
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Motohiro Tamiya
    Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Takashi Kijima
    Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Yuki Sato
    Systems and Information Engineering Master's Program in Computer Science, University of Tsukuba, 1-1-1 Tenoudai, Tsukuba City, Ibaraki, 305-0821, Japan. s2220599@u.tsukuba.ac.jp.
  • Akito Hata
    Division of Thoracic Oncology, Kobe Minimally Invasive Cancer Center, Kobe, Japan.
  • Toshihide Yokoyama
    Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Japan.
  • Yoshihiko Taniguchi
    Department of Internal Medicine, NHO Kinki Chuo Chest Medical Center, Sakai, Japan.
  • Junji Uchida
  • Hisashi Tanaka
    Division of Health Science, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Naoki Furuya
    Division of Respiratory Medicine, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Satoru Miura
    Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan.
  • Mihoko Imaji Onishi
    Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
  • Shinya Sakata
    Department of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.
  • Eisaku Miyauchi
    Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Nobuyuki Yamamoto
    Department of Pulmonary Medicine and Medical Oncology, Wakayama Medical University, Wakayama, Japan.
  • Yasuhiro Koh
    Internal Medicine III, Wakayama Medical University, Wakayama, Japan; Center for Biomedical Sciences, Wakayama Medical University, Wakayama, Japan.
  • Hiroaki Akamatsu
    Internal Medicine III, Wakayama Medical University, Wakayama, Japan.

Keywords

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