G2M-checkpoint related immune barrier structure and signature for prognosis and immunotherapy response in hepatocellular carcinoma: insights from spatial transcriptome and machine learning.

Journal: Journal of translational medicine
PMID:

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) treatment remains challenging, particularly for immune checkpoint inhibitors (ICIs) non-response patients. Spatial transcriptome (ST) data and machine learning algorithms offer new insights into understanding HCC heterogeneity and ICIs resistance mechanisms.

Authors

  • Xingte Chen
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
  • Shiji Wu
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
  • Hongxin He
    Center for Systems Biology, Soochow University, Suzhou 215006, Jiangsu, China.
  • Jingjing Tang
    School of Business Administration, Southwestern University of Finance and Economics, Chengdu 611130, China. Electronic address: tangjingjing13@mails.ucas.ac.cn.
  • Yaqi Zhong
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
  • Huipeng Fang
    Department of General Surgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, China.
  • Qizhen Huang
    Department of Radiation Oncology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
  • Liang Hong
    Department of Computer Science and Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR 999077, China.
  • Lingdong Shao
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital, (Fujian Branch of Fudan University Shanghai Cancer Center), Fujian Cancer Hospital, Fuzhou, China.
  • Junxin Wu
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital, (Fujian Branch of Fudan University Shanghai Cancer Center), Fujian Cancer Hospital, Fuzhou, China.