Combining multi-omics analysis with machine learning to uncover novel molecular subtypes, prognostic markers, and insights into immunotherapy for melanoma.

Journal: BMC cancer
PMID:

Abstract

BACKGROUND: Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatment options. Our study aims to identify key target genes and enhance the diagnostic accuracy of melanoma prognosis by employing multi-omics analysis and machine learning techniques, ultimately leading to the development of novel therapeutic strategies.

Authors

  • Songyun Zhao
    Department of Neurosurgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
  • Zihao Li
    School of Mechanical Engineering and Automation, Harbin Institute of Technology(Shenzhen), Shenzhen, 518055, China.
  • Kaibo Liu
    Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Gaoyi Wang
    Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Quanqiang Wang
    Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Hua Yu
    School of Computer Science and Technology, Tianjin University, Nankai District, Tianjin 300072, China. yuhua@tju.edu.cn.
  • Wanying Chen
    Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, 130000, China.
  • Hao Dai
    Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL.
  • Yijun Li
    School of Integrated Circuits, Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University, Beijing 100084, China.
  • Jiaheng Xie
    Department of Management Information Systems, University of Arizona, Tucson, AZ, USA.
  • Yucang He
    Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. heyucang0@163.com.
  • Liqun Li
    Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wz.llq@wmu.edu.cn.