Prediction of remission of pharmacologically treated psychotic depression: A machine learning approach.

Journal: Journal of affective disorders
PMID: 40187431

Abstract

BACKGROUND: The combination of antidepressant and antipsychotic medication is an effective treatment for major depressive disorder with psychotic features ('psychotic depression'). The present study aims to identify sociodemographic and clinical predictors of remission of psychotic depression treated with combination pharmacotherapy and determine the accuracy of prediction models.

Authors

  • Emily Carter
    Department of Population Health Sciences, Weill Cornell Medicine, New York, USA.
  • Samprit Banerjee
    Department Population Health Sciences, Weill Cornell Medicine, New York, USA. Electronic address: sab2028@med.cornell.edu.
  • George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains, NY. Electronic address: gsalexop@med.cornell.edu.
  • Kathleen S Bingham
    Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Canada; Centre for Mental Health, University Health Network, Toronto, Canada.
  • Patricia Marino
    Department of Psychiatry, Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, New York, USA.
  • Barnett S Meyers
    Department of Psychiatry, Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, New York, USA.
  • Benoit H Mulsant
    Department of Psychiatry, University of Toronto, Toronto, Canada.
  • Nicholas H Neufeld
    Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.
  • Anthony J Rothschild
    University of Massachusetts Chan Medical School and UMass Memorial Health Care, Worcester, USA.
  • Aristotle N Voineskos
    Kimel Family Translational Imaging-Genetics Research Lab, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Geriatric Mental Health Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine and UPMC Western Psychiatric Hospital, Pittsburgh, USA.
  • Alastair J Flint
    Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Canada; Centre for Mental Health, University Health Network, Toronto, Canada. Electronic address: alastair.flint@uhn.ca.

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