Major depressive disorder (MDD) presents a substantial health burden with low treatment response rates. Predicting antidepressant efficacy is challenging due to MDD's complex and varied neuropathology. Identifying biomarkers for antidepressant treatm...
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Sep 17, 2024
OBJECTIVE: Predicting an individual's response to antidepressant medication remains one of the most challenging tasks in the treatment of major depressive disorder (MDD). Our objective was to use the large EMBARC study database to develop an electroe...
Expert review of clinical pharmacology
Jan 29, 2024
BACKGROUND: Variability exists in sertraline pharmacokinetic parameters in individuals, especially obvious in adolescents. We aimed to establish an individualized dosing model of sertraline for adolescents with depression based on artificial intellig...
IMPORTANCE: Despite the high prevalence and potential outcomes of major depressive disorder, whether and how patients will respond to antidepressant medications is not easily predicted.
Selective serotonin reuptake inhibitors (SSRIs) like sertraline are crucial in treating depression and anxiety disorders, and studies indicate their potential as chemosensitizers in cancer therapy. This research develops a machine-learning predictive...
BACKGROUND: The combination of antidepressant and antipsychotic medication is an effective treatment for major depressive disorder with psychotic features ('psychotic depression'). The present study aims to identify sociodemographic and clinical pred...
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