Automated Imaging Differentiation for Parkinsonism.

Journal: JAMA neurology
PMID:

Abstract

IMPORTANCE: Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progressive supranuclear palsy (PSP). A prospective study is needed to test whether the approach meets primary end points to be considered in a diagnostic workup.

Authors

  • David E Vaillancourt
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Angelos Barmpoutis
    J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.
  • Samuel S Wu
    Department of Biostatistics, University of Florida, Gainesville.
  • Jesse C DeSimone
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville.
  • Marissa Schauder
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville.
  • Robin Chen
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville.
  • Todd B Parrish
    Department of Radiology, Northwestern University, Chicago, IL.
  • Wei-En Wang
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville.
  • Eric Molho
    Parkinson's Disease and Movement Disorders Center, Albany Medical Center, Albany, New York.
  • John C Morgan
    Department of Neurology, Medical College of Georgia at Augusta University, Augusta.
  • David K Simon
    Department of Neurology, Harvard Medical School, Boston, Massachusetts.
  • Burton L Scott
    iMIND Research Group, Duke University School of Medicine, Durham, NC, USA.
  • Liana S Rosenthal
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Stephen N Gomperts
    Department of Neurology, Harvard Medical School, Boston, Massachusetts.
  • Rizwan S Akhtar
    Ken and Ruth Davee Department of Neurology, Parkinson's Disease and Movement Disorders Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • David Grimes
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Sol De Jesus
    Department of Neurology, College of Medicine, Pennsylvania State University, Hershey.
  • Natividad Stover
    Department of Neurology, University of Alabama at Birmingham, Birmingham.
  • Ece Bayram
    Department of Neurosciences, University of California, San Diego.
  • Adolfo Ramirez-Zamora
  • Stefan Prokop
    Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
  • Ruogu Fang
    J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.
  • John T Slevin
    Department of Neurology, University of Kentucky, Lexington.
  • Prabesh Kanel
    Department of Radiology, University of Michigan, Ann Arbor.
  • Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI.
  • Paul Tuite
    Department of Neurology, University of Minnesota, Minneapolis.
  • Stephen Aradi
    Department of Neurology, University of South Florida, Tampa.
  • Antonio P Strafella
    Krembil Brain Institute, University Health Network (UHN), Toronto, Ontario, Canada; Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Edmond J. Safra Parkinson Disease Program & Morton and Gloria Shulman Movement Disorder Unit, Neurology Division, Toronto Western Hospital, UHN, Toronto, Ontario, Canada. Electronic address: antonio.strafella@utoronto.ca.
  • Mustafa S Siddiqui
    Department of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Albert A Davis
    Department of Neurology, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Xuemei Huang
    School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
  • Jill L Ostrem
    Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.
  • Hubert Fernandez
    Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, Ohio.
  • Irene Litvan
    Department of Neurosciences, University of California, San Diego.
  • Robert A Hauser
    Department of Neurology, University of South Florida, Tampa.
  • Alexander Pantelyat
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Nikolaus R McFarland
    Fixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL.
  • Tao Xie
    Department of Neurology, University of Chicago Medicine, Chicago, IL.
  • Michael S Okun
    Fixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL.
  • Alicia Leader
    Parkinson's Disease and Movement Disorders Center, Albany Medical Center, Albany, New York.
  • Áine Russell
    Beth Israel Deaconess Medical Center, Boston, Massachusetts.
  • Hannah Babcock
    Beth Israel Deaconess Medical Center, Boston, Massachusetts.
  • Karen White-Tong
    Department of Neurology, Duke University Medical Center, Durham, North Carolina.
  • Jun Hua
    F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Anna E Goodheart
    Department of Neurology, Harvard Medical School, Boston, Massachusetts.
  • Erin Colleen Peterec
    Department of Neurology, Harvard Medical School, Boston, Massachusetts.
  • Cynthia Poon
    5Department of Neurology, Northwestern University, Chicago, IL 60611 USA.
  • Max B Galarce
    Ken and Ruth Davee Department of Neurology, Parkinson's Disease and Movement Disorders Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Tanya Thompson
    The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Autumn M Collier
    Department of Neurology, College of Medicine, Pennsylvania State University, Hershey.
  • Candace Cromer
    Department of Neurology, University of Alabama at Birmingham, Birmingham.
  • Natt Putra
    Department of Neurosciences, University of California, San Diego.
  • Reilly Costello
    Department of Neurosciences, University of California, San Diego.
  • Eda Yilmaz
    Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.
  • Crystal Mercado
    Department of Neurology, University of Chicago, Chicago, Illinois.
  • Tomas Mercado
    Department of Neurology, University of Chicago, Chicago, Illinois.
  • Amanda Fessenden
    Department of Neurology, University of Florida, Gainesville.
  • Renee Wagner
    Department of Neurology, University of Kentucky, Lexington.
  • C Chauncey Spears
    Department of Neurology, University of Michigan, Ann Arbor.
  • Jacqueline L Caswell
    Department of Radiology, University of Michigan, Ann Arbor.
  • Marina Bryants
    Department of Neurology, University of Minnesota, Minneapolis.
  • Kristyn Kuzianik
    Department of Neurology, University of South Florida, Tampa.
  • Youshra Ahmed
    Department of Neurology, University of South Florida, Tampa.
  • Nathaniel Bendahan
    Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.
  • Joy O Njoku
    Department of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Amy Stiebel
    Department of Neurology, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • Hengameh Zahed
    Department of Neurology, Stanford Movement Disorders Center, Stanford University, Palo Alto, California.
  • Sarah S Wang
    Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.
  • Phuong T Hoang
    Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.
  • Joseph Seemiller
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Guangwei Du
    Department of Neurology, Penn State - Milton S. Hershey Medical Center, Hershey, PA.