Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal: Journal of translational medicine
PMID: 40346550

Abstract

BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular tone, endothelial function, and inflammation. Our objectives were to identify proteins specifically secreted by foam human coronary VSMCs (foam-hcVSMC) to evaluate their potential as circulating biomarkers for diagnosing coronary artery disease (CAD), and to ascertain the mechanisms underlying their levels in the blood of patients with CAD.

Authors

  • Eduardo Garcia
    Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.
  • Lene Claudi
    Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.
  • Maria Teresa La Chica Lhoëst
    Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.
  • Anna Polishchuk
    Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.
  • Valerie Samouillan
    CIRIMAT, Université de Toulouse, Université Paul Sabatier, Equipe PHYPOL, 31062, Toulouse, France.
  • Aleyda Benitez Amaro
    Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.
  • Janet Piñero
    Medbioinformatics Solutions SL, Barcelona, Spain.
  • Joan Carles Escolà-Gil
    Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, 08041, Barcelona, Spain.
  • Eduard Sabidó
    Proteomics Unit, Centre de Regulació Genòmica, Barcelona Institute of Science and Technology; Universitat Pompeu i Fabra (UPF), Barcelona, Spain.
  • Ruben Leta
    Cardiac Imaging Unit, Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
  • David Vilades
    Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, 08041, Barcelona, Spain.
  • Vicenta Llorente Cortes
    Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain. vicenta.llorente@iibb.csic.es.

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