AIMC Topic: Foam Cells

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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal of translational medicine May 9, 2025
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
Humans Biomarkers Female Aged Male Middle Aged Case-Control Studies ROC Curve Coronary Artery Disease Cell Hypoxia Myocytes, Smooth Muscle Guanine Nucleotide Exchange Factors Foam Cells
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Label-Free Tomographic Imaging of Lipid Droplets in Foam Cells for Machine-Learning-Assisted Therapeutic Evaluation of Targeted Nanodrugs.

ACS nano Jan 10, 2020
Lipid droplet (LD) accumulation, a key feature of foam cells, constitutes an attractive target for therapeutic intervention in atherosclerosis. However, despite advances in cellular imaging techniques, current noninvasive and quantitative methods hav...
Machine Learning Cells, Cultured Animals Imaging, Three-Dimensional Mice Nanoparticles Particle Size Atherosclerosis RAW 264.7 Cells Surface Properties Thiazolidinediones Pyrimidines Foam Cells Tomography, Optical Lipid Droplets
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