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Guanine Nucleotide Exchange Factors

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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal of translational medicine 40346550
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
Aged Biomarkers Case-Control Studies Cell Hypoxia Coronary Artery Disease Female Foam Cells Guanine Nucleotide Exchange Factors Humans Male Middle Aged Myocytes, Smooth Muscle ROC Curve
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