Machine learning-driven identification of exosome- related biomarkers in head and neck squamous cell carcinoma.

Journal: Frontiers in immunology
Published Date: May 22, 2025

Abstract

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a common cancer associated with elevated mortality rates. Exosomes, diminutive extracellular vesicles, significantly contribute to tumour development, immunological evasion, and treatment resistance. Identifying exosome-associated biomarkers in HNSCC may improve early diagnosis, treatment targeting, and patient classification.

Authors

  • Yaodong He
    Center of Marine Environmental Ecology, School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China.
  • Yun Li
    School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Jiaqi Tang
    State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
  • Yan Wang
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Zhenyan Zhao
    State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
  • Rong Liu
    School of Biomedical Engineering, Dalian University of Technology, Dalian, China.
  • Zihui Yang
    State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
  • Huan Li
    National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
  • Jianhua Wei
    State Key Laboratory of Military Stomatology, Department of Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University, Xi'an, China.

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