Integration of Deep Learning and Sub-regional Radiomics Improves the Prediction of Pathological Complete Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Patients.

Journal: Academic radiology
Published Date: Jan 13, 2025

Abstract

RATIONALE AND OBJECTIVES: The precise prediction of response to neoadjuvant chemoradiotherapy is crucial for tailoring perioperative treatment in patients diagnosed with locally advanced rectal cancer (LARC). This retrospective study aims to develop and validate a model that integrates deep learning and sub-regional radiomics from MRI imaging to predict pathological complete response (pCR) in patients with LARC.

Authors

  • Xixi Wu
    Nanjing Medical University, Nanjing, China.
  • Jinyong Wang
    Department of Infectious, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China (J.W., K.G.); Department of Pathology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou 325000, China (X.W., J.W., C.C., W.C., Y.G., K.G., Y.C., Y.S., J.C., X.L., X.J.). Electronic address: 583670905@qq.com.
  • Chao Chen
    Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Weimin Cai
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Yu Guo
    Animal Disease Control Center of Inner Mongolia, Hohhot, China.
  • Kun Guo
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Yongxian Chen
    Department of Chest Cancer, Xiamen Second People's Hospital, Xiamen, 36100, China.
  • Yubo Shi
    Department of Pulmonary, Yueqing People's Hospital, Wenzhou, 325000, China.
  • Junkai Chen
    Department of Emergency, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, 325000, China. jkcwz96@126.com.
  • Xinran Lin
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Xuepei Jiang
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China (X.W., C.C., W.C., Y.G., X.L., X.J.); Department of Pathology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou 325000, China (X.W., J.W., C.C., W.C., Y.G., K.G., Y.C., Y.S., J.C., X.L., X.J.). Electronic address: wmcjxp16@126.com.

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