Machine Learning Prediction of Pancreatitis Risk With Antithyroid Drugs: A Nationwide Retrospective Observational Study.

Journal: The Journal of clinical endocrinology and metabolism
Published Date: Jun 17, 2025

Abstract

BACKGROUND: In recent years, there has been increasing data showing that the risk of acute pancreatitis (AP) is increased in patients using methimazole (MMI). The aim of this population-based study was to investigate the association between drugs used in the treatment of hyperthyroidism (MMI, propylthiouracil, propranolol) and the diagnosis of AP.

Authors

  • Muhammed Kizilgul
    1 Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey.
  • Talip Yigit
    Faculty of Economics and Administrative Sciences, Istanbul 29 Mayıs University, 34764 Istanbul, Türkiye.
  • Naim Ata
    Turkish Ministry of Health, General Directorate of Health Information System, 06434 Ankara, Türkiye.
  • Ahmet Celik
    Faculty of Medicine, Department of Cardiology, Mersin University, 33110 Mersin, Türkiye.
  • Bekir Ucan
    1 Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey.
  • Mustafa Sahin
    Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • M Mahir Ulgu
    Turkish Ministry of Health, General Directorate of Health Information System, 06434 Ankara, Türkiye.
  • Şuayip Birinci
    Ministry of Health, Ankara, Türkiye.

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