Prognostic value of circadian rhythm-associated genes in breast cancer.
Journal:
World journal of surgical oncology
Published Date:
May 14, 2025
Abstract
OBJECTIVE: Breast cancer (BC) remains the most prevalent malignancy among women. Clinical evidence indicates that genetic variations related to circadian rhythms, as well as the timing of therapeutic interventions, influence the response to radiation therapy and the toxicity of pharmacological treatments in women with BC. This study aimed to identify key circadian rhythm-related genes (CRGs) using bioinformatics and machine learning, and construct a prognostic model to predict clinical outcomes.
