From resting-state functional hippocampal centrality to functional outcome: An extended neurocognitive model of psychosis.

Journal: Psychiatry research
Published Date: May 16, 2025

Abstract

BACKGROUND: We previously proposed a neurocognitive model of psychosis in which reduced morphometric hippocampal-cortical connectivity precedes impaired episodic memory, social cognition, negative symptoms, and functional outcome. We provided support for this model in a patient subtype, and aimed to extend these findings to resting-state functional MRI to potentially explain the progression for a broader range of patients.

Authors

  • Jana F Totzek
    Department of Psychiatry, McGill University, Irving Ludmer Psychiatry Research and Training Building, 1033 Pine Ave W, Montreal, Quebec, H3A 1A1. Canada; Douglas Research Centre. 6875 Blvd. LaSalle, Verdun, Quebec, H4H 1R3. Canada. Electronic address: jana.totzek@mail.mcgill.ca.
  • Jai L Shah
    Department of Psychiatry, McGill University, Irving Ludmer Psychiatry Research and Training Building, 1033 Pine Ave W, Montreal, Quebec, H3A 1A1. Canada; Douglas Research Centre. 6875 Blvd. LaSalle, Verdun, Quebec, H4H 1R3. Canada. Electronic address: jai.shah@mcgill.ca.
  • Alexandra L Young
    Centre for Medical Image Computing (CMIC), Department of Computer Science, Faculty of Engineering Sciences, University College London, London, UK.
  • Ashok Malla
    Department of Psychiatry, McGill University, Irving Ludmer Psychiatry Research and Training Building, 1033 Pine Ave W, Montreal, Quebec, H3A 1A1. Canada; Douglas Research Centre. 6875 Blvd. LaSalle, Verdun, Quebec, H4H 1R3. Canada. Electronic address: ashok.malla@mcgill.ca.
  • Ridha Joober
    Douglas Research Centre, Montreal, QC, Canada.
  • Delphine Raucher-Chéné
    Department of Psychiatry, McGill University, Irving Ludmer Psychiatry Research and Training Building, 1033 Pine Ave W, Montreal, Quebec, H3A 1A1. Canada; Douglas Research Centre. 6875 Blvd. LaSalle, Verdun, Quebec, H4H 1R3. Canada. Electronic address: delphine.raucher-chene@mcgill.ca.
  • Martin Lepage
    Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada; Department of Psychiatry, McGill University, 845 Sherbrooke Street West, Montreal, Quebec H3A 0G4, Canada.
  • Katie M Lavigne
    Department of Psychiatry, McGill University, Irving Ludmer Psychiatry Research and Training Building, 1033 Pine Ave W, Montreal, Quebec, H3A 1A1. Canada; Douglas Research Centre. 6875 Blvd. LaSalle, Verdun, Quebec, H4H 1R3. Canada. Electronic address: katie.lavigne@mcgill.ca.

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