Development and validation of a nomogram for differentiating immune checkpoint inhibitor-related pneumonitis from pneumonia in patients undergoing immunochemotherapy: a multicenter, real-world, retrospective study.

Journal: Frontiers in immunology
Published Date: May 19, 2025

Abstract

BACKGROUND: Immune Checkpoint Inhibitor-related Pneumonitis (CIP) exhibits high morbidity and mortality rates in the real world, often coexisting with pneumonia, particularly after immunochemotherapy. We aimed to develop and validate a non-invasive nomogram for differentiating CIP from pneumonia in patients undergoing immunochemotherapy.

Authors

  • Linli Duan
    Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Guanglu Liu
    Algorithm Development Department 1, GRGBanking Equipment Company Ltd., Guangzhou, China.
  • Zijie Huang
    Department of Neurology, West China Hospital, Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu, China, 86 18980605819.
  • Rong Chen
    Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Di Mo
    Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Yuxiao Xia
    Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Jiazhu Hu
    Department of Oncology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Mengzhang He
    Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

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