GALR1 and PENK serve as potential biomarkers in invasive non-functional pituitary neuroendocrine tumours.

Journal: Gene
Published Date: Feb 28, 2025

Abstract

BACKGROUND: Some nonfunctioning pituitary neuroendocrine tumor (NFPitNET) can show invasive growth, which increases the difficulty of surgery and indicates a poor prognosis. However, the molecular mechanism related to invasiveness remains to be further studied. This study is to screen and identify the characteristic biomarkers of invasive NFPitNETs.

Authors

  • Zerui Wu
    Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
  • Changjun Rao
    Department of Cell Biology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
  • Yilin Xie
    Department of Information Science and Technology, Northwest University, Xi'an, Shaanxi 710127, China.
  • Zhen Ye
    School of Medicine, Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
  • Yichao Zhang
  • Zengyi Ma
    State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, China. Electronic address: mazy@zju.edu.cn.
  • Zhipeng Su
    Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: drsuzhipeng@163.com.
  • Zhao Ye
    Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address: yezhaozj663812@126.com.

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