Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.
Journal:
Frontiers in immunology
Published Date:
May 22, 2025
Abstract
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment (TME), the metabolic heterogeneity of CRC cells and their interactions with tumor-infiltrating immune cells remain poorly understood.
Authors
Keywords
Amino Acids
CD8-Positive T-Lymphocytes
Cell Line, Tumor
Colorectal Neoplasms
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Lymphocytes, Tumor-Infiltrating
Male
Prognosis
Programmed Cell Death 1 Receptor
Single-Cell Analysis
Transcriptome
Tumor Escape
Tumor Microenvironment
