AIMC Topic: Tumor Escape

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Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Scientific reports Jul 8, 2025
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Despite advancements in treatment, prognosis for patients with advanced stages remains poor. Metabolic reprogramming in the tumor microenvironment, particularly...
Humans Prognosis Tumor Microenvironment Lung Neoplasms Glycolysis Gene Expression Regulation, Neoplastic Carcinoma, Non-Small-Cell Lung CD8-Positive T-Lymphocytes Drug Resistance, Neoplasm L-Lactate Dehydrogenase Immune Evasion Tumor Escape Lactate Dehydrogenase 5
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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.

Frontiers in immunology May 22, 2025
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...
Humans Prognosis Female Colorectal Neoplasms Tumor Microenvironment Male Gene Expression Profiling Transcriptome Cell Line, Tumor Single-Cell Analysis Gene Expression Regulation, Neoplastic Lymphocytes, Tumor-Infiltrating CD8-Positive T-Lymphocytes Amino Acids Programmed Cell Death 1 Receptor Tumor Escape
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Machine learning-based discovery of UPP1 as a key oncogene in tumorigenesis and immune escape in gliomas.

Frontiers in immunology Sep 24, 2024
INTRODUCTION: Gliomas are the most common and aggressive type of primary brain tumor, with a poor prognosis despite current treatment approaches. Understanding the molecular mechanisms underlying glioma development and progression is critical for imp...
Humans Machine Learning Prognosis Biomarkers, Tumor Brain Neoplasms Animals Cell Line, Tumor Mice Gene Expression Regulation, Neoplastic Glioma Carcinogenesis Oncogenes Tumor Escape
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