Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq.

Journal: Frontiers in immunology
Published Date: May 28, 2025

Abstract

BACKGROUND: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophagy in the pathogenesis of severe acute pancreatitis (SAP) has not been fully investigated. In this study, we aimed to identify crucial mitophagy-related genes in SAP to provide a theoretical basis for in-depth mechanistic investigations.

Authors

  • Xiaozhou Xie
    Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Zheng Wang
    Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Haoyu Zhang
    School of Information Engineering, Zhejiang Ocean University, Zhoushan, China. haoyu19871202@163.com.
  • Jiongdi Lu
    Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Feng Cao
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
  • Fei Li
    Institute for Precision Medicine, Tsinghua University, Beijing, China.

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