Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion.

Journal: Frontiers in endocrinology
Published Date:

Abstract

BACKGROUND: Ischemic cardiomyopathy is a severe disease marked by high morbidity and mortality, often exacerbated by myocardial ischemia/reperfusion injury (MI/RI). Mitochondrial metabolism plays a critical role in MI/RI progression. This study aimed to identify potential new targets and biomarkers for mitochondria-related genes in MI/RI.

Authors

  • Hong Li
    Department of Public Health Sciences, Medical College of South Carolina, Charleston, SC.
  • Yixin Zhou
    Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China.
  • Wenya Xue
    Department of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Pan Yin
    Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Luyu Liu
    Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Shaobo Wu
    Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Yahao Zhao
    Department of General Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
  • Qi An
    School of Information Technology, Faculty of Science, Engineering and Built Environment, Deakin University, Geelong, VIC 3216, Australia.
  • Yang Sun
    Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.