Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety.

Journal: BMC psychiatry
Published Date: May 30, 2025

Abstract

BACKGROUND: Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Identifying patient characteristics predictive of higher post-treatment symptom severity is crucial for devising personalized interventions to avoid treatment failures and reduce healthcare costs.

Authors

  • Olly Kravchenko
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden. olly.kravchenko@ki.se.
  • Julia Bäckman
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden.
  • David Mataix-Cols
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • James J Crowley
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden.
  • Matthew Halvorsen
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden.
  • Patrick F Sullivan
    Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Sullivan); Medical Research Center for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Wales, United Kingdom (Owen).
  • John Wallert
    Department of Public Health and Caring Sciences, Uppsala University, Box 564, Husargatan 3, SE - 75122, Uppsala, Sweden. john.wallert@kbh.uu.se.
  • Christian Rück
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Keywords

External Resources

Popular Topics
Recent Journals