Development of a Diagnostic Prediction Model for Post-Stroke Cognitive Impairment in Acute Large Vessel Occlusion Stroke Using Multimodal MRI and PET/CT: A Study Protocol.

Journal: Brain and behavior
Published Date: Jun 1, 2025

Abstract

OBJECTIVE: Stroke is a leading cause of morbidity and disability worldwide. Post-stroke cognitive impairment (PSCI) significantly affects long-term prognosis in acute anterior circulation large-vessel occlusion stroke (LVO-AIS). This study aims to develop a PSCI prediction model integrating multimodal imaging, demographic, and clinical data collected during hospitalization.

Authors

  • Junhao Li
    Department of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
  • Yuding Luo
    Department of Neurology, Ya'an People's Hospital, Ya'an, China.
  • Pingchuan Liu
    Department of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
  • Jiali Zhang
    Graduate School, Beijing University of Chinese Medicine, Beijing, China.
  • Chuanxi Duan
    North Sichuan Medical College, Nanchong, China.
  • Hai Xiong
    School of Medicine, Tibet University, Lhasa, 850000, China. xhxysq@126.com.
  • Maoxia Li
    Department of Neurology, Ya'an People's Hospital, Ya'an, China.
  • Binyang Zhang
    Department of Neurology, Ya'an People's Hospital, Ya'an, China.
  • Lu Li
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
  • Lulu Gong
    Department of Radiology, Ya'an People's Hospital, Ya'an, China.
  • Yupeng Niu
    College of Information Engineering, Sichuan Agricultural University, Ya'an, 625000, China.
  • Bo Zheng
    State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
  • Jian Wang
    Veterinary Diagnostic Center, Shanghai Animal Disease Control Center, Shanghai, China.

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