Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Accelerated Brain Ageing: A Population-Based Study.

Journal: Liver international : official journal of the International Association for the Study of the Liver
Published Date: Jun 1, 2025

Abstract

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to cognitive decline and dementia risk. We aimed to investigate the association between MASLD and brain ageing and explore the role of low-grade inflammation.

Authors

  • Jiao Wang
    Key Lab of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Rongrong Yang
    College of Tourist and Environment Science, Shaanxi Normal University, Xi'an, 710119, Shaanxi, China.
  • Yuyang Miao
    Tianjin Key Laboratory of Elderly Health, Department of Geriatrics, Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, China.
  • Xinjie Zhang
    State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, China.
  • Stéphanie Paillard-Borg
    Department of Health Sciences, The Swedish Red Cross University, Huddinge, Sweden.
  • Zhongze Fang
    Department of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China.
  • Weili Xu
    Taizhou Environmental Monitoring Center Station, Taizhou 318000, China.

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