Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

Journal: Oral oncology
Published Date: Apr 16, 2025

Abstract

OBJECTIVE: Despite growing interest in neoadjuvant therapies, there are no methods to predict radio- (RT) or chemoradiotherapy (CRT) response in head and neck squamous cell carcinoma (HNSCC). The aim of this research was to study the effect of neoadjuvant RT or CRT on the tumor immune landscape and patient survival in HNSCC.

Authors

  • A R Koskenniemi
    Department of Pathology, Laboratory Division, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address: anna-riina.koskenniemi@varha.fi.
  • T Huusko
    Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland.
  • J Routila
    Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
  • S Jalkanen
    MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland.
  • M Hollmén
    MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland.
  • P Vainio
    Department of Pathology, Laboratory Division, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.
  • S Ventelä
    Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; FICAN West Cancer Centre, Turku, Finland.

Keywords

External Resources

Popular Topics
Recent Journals