Structural brain pattern abnormalities in tinnitus with and without hearing loss.

Journal: Hearing research
Published Date: Apr 6, 2025

Abstract

OBJECTIVE: Subjective tinnitus often coexists with hearing loss, and they share common pathophysiological mechanisms. This comorbidity induces whole-brain gray matter volume (GMV) alterations, manifesting as distributed structural changes in neural networks rather than isolated regional modifications. Multivariate analysis of structural brain patterns is therefore essential to differentiate their underlying mechanisms.

Authors

  • Li Qin
    School of Electrical Engineering, Yanshan University, Qinhuangdao 066012, China.
  • Qiu Ge
    Centre for Cognition and Brain Disorders/Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, PR China; Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, PR China. Electronic address: geqiu@hznu.edu.cn.
  • Chaoqi Shi
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, PR China. Electronic address: 690291945@qq.com.
  • Jiayu Ni
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, PR China.
  • Zili Yin
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, PR China.
  • Enli Jin
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, PR China.
  • Jiaying Wang
    Key Laboratory of Electronic Engineering of Heilongjiang Province, Heilongjiang University, Harbin 150080, China. Electronic address: Wangjy9506@126.com.
  • Yu-Feng Zang
    Centre for Cognition and Brain Disorders/Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, PR China; Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, PR China; TMS center, Deqing Hospital of Hangzhou Normal University, Deqing, Zhejiang, PR China. Electronic address: zangyf@hznu.edu.cn.
  • Yuan Li
    NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.

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