Artificial intelligence-based multimodal prediction for nuclear grading status and prognosis of clear cell renal cell carcinoma: a multicenter cohort study.

Journal: International journal of surgery (London, England)
Published Date: Mar 28, 2025

Abstract

BACKGROUND: The assessment of the International Society of Urological Pathology (ISUP) nuclear grade is crucial for the management and treatment of clear cell renal cell carcinoma (ccRCC). This study aimed to explore the value of using integrated multimodal information for ISUP grading and prognostic stratification in ccRCC patients, to guide postoperative adjuvant therapy.

Authors

  • Qingyuan Zheng
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Haonan Mei
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China; Institute of Urologic Disease, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Xiaodong Weng
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Rui Yang
    Department of Biomedical Informatics, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.
  • Panpan Jiao
    Department of Urology, Renmin Hospital of Wuhan University, 99 Zhang Zhi-Dong Road, Wuhan, 430060, Hubei, People's Republic of China.
  • Xinmiao Ni
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Xiangxiang Yang
    Department of Urology, Renmin Hospital of Wuhan University, 99 Zhang Zhi-dong Road, Wuhan, Hubei, 430060, P.R. China.
  • Jiejun Wu
    Department of Urology, Renmin Hospital of Wuhan University, 99 Zhang Zhi-Dong Road, Wuhan, 430060, Hubei, People's Republic of China.
  • Junjie Fan
  • Jingping Yuan
    Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Xiuheng Liu
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Zhiyuan Chen
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

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