Validation and Derivation of miRNA-Based Germline Signatures Predicting Radiation Toxicity in Prostate Cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date: Jun 13, 2025

Abstract

PURPOSE: Although radiotherapy (RT) is one of the primary treatment modalities used in the treatment of cancer, patients often experience toxicity during or after treatment. RT-induced genitourinary (GU) toxicity is a significant survivorship challenge for patients with prostate cancer, but identifying those at risk has been challenging. Herein, we attempt (i) to validate a previously identified biomarker of late RT-induced GU toxicity, PROSTOX, consisting primarily of miRNA-based germline biomarkers (mirSNPs), and (ii) investigate the possibility of temporally and genetically defining other forms of RT-associated GU toxicity.

Authors

  • Amar U Kishan
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Kristen McGreevy
    Department of Biostatistics, University of California Los Angeles, Los Angeles, California.
  • Luca Valle
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Michael Steinberg
    Department of Psychiatry, University of Pennsylvania.
  • Beth Neilsen
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Maria Casado
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.
  • Minsong Cao
    Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
  • Donatello Telesca
  • Joanne B Weidhaas
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.

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