Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.

Journal: Heart (British Cardiac Society)
Published Date:

Abstract

BACKGROUND: Epicardial adipose tissue represents a metabolically active visceral fat depot that is in direct contact with the left ventricular myocardium. While it is associated with coronary artery disease, little is known regarding its role in aortic stenosis. We sought to investigate the association of epicardial adipose tissue with aortic stenosis severity and progression, myocardial remodelling and function, and mortality in asymptomatic patients with aortic stenosis.

Authors

  • Jolien Geers
    Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (R.J.J.M., N.M., A.L., A.S., C.P., A.K., P.M., A.R., K.G., A.C.K., D.H., K.K., G.F.T., J.G., H.G., S.C., D.S.B., P.J.S., D.D.).
  • Nipun Manral
    Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Aryabod Razipour
    Biomedical Imaging Research Institute (P.A.M., F.C., X.C., M.G., A.R., D.D.), Cedars-Sinai Medical Center, Los Angeles, CA.
  • Caroline Park
    Institute of Medical Science, University of Toronto, Toronto, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada.
  • Guadalupe Flores Tomasino
    Biomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Emily Xing
    Biomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Kajetan Grodecki
    Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
  • Jacek Kwiecinski
    Division of Artificial Intelligence in Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
  • Tania Pawade
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
  • Mhairi K Doris
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
  • Rong Bing
    Centre for Cardiovascular Science, University of Edinburgh, Chancellors Building, Little France Crescent, Edinburgh, EH16 4SB, UK.
  • Audrey C White
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
  • Steven Droogmans
    Department of Cardiology, Universitair Ziekenhuis Brussel, Jette, Belgium.
  • Bernard Cosyns
    Cardiology, Center of Heart Disease, Universitair Ziekenhuis Brussel, Vrij Universiteit Brussel, Brussels, Belgium. Electronic address: bcosyns@uzbrussel.be.
  • Piotr J Slomka
    Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California Piotr.Slomka@cshs.org.
  • David E Newby
    Edinburgh Imaging Facility QMRI, Edinburgh, EH16 4TJ, UK; Centre for Cardiovascular Science, Edinburgh, EH16 4TJ, UK.
  • Marc R Dweck
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Cres, Edinburgh, UK.
  • Damini Dey
    Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA.