Integrating WGCNA and SVM-RFE identifies hub molecular biomarkers driving ischemic stroke progression.

Journal: Neurological research
Published Date:

Abstract

BACKGROUND: Stroke is the second most common cause of death worldwide and the leading cause of long-term severe disability with neurological impairment worsening within hours after stroke onset and being especially involved with motor function. So far, there are no established and reliable biomarkers to prognose stroke. Early detection of biomarkers that can prognose stroke is of great importance for clinical intervention and prevention of clinical deterioration of stroke.

Authors

  • You Zhang
    Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Lin-Xing Huang
    College of Acupuncture, Massage and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
  • Zeng-Hui Yue
    Key Acu-moxibustion Laboratory of Biological Information Analysis of Institute of Acupuncture, Moxibustion and Massage, Hunan University of Chinese Medicine, Changsha 410007, China.