Derivation and validation of an artificial intelligence-based plaque burden safety cut-off for long-term acute coronary syndrome from coronary computed tomography angiography.

Journal: European heart journal. Cardiovascular Imaging
Published Date:

Abstract

AIMS: Artificial intelligence (AI) has enabled accurate and fast plaque quantification from coronary computed tomography angiography (CCTA). However, AI detects any coronary plaque in up to 97% of patients. To avoid overdiagnosis, a plaque burden safety cut-off for future coronary events is needed.

Authors

  • Sarah Bär
    Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Cardiology, Bern University Hospital Inselspital, Bern, Switzerland.
  • Juhani Knuuti
    Turku PET Centre, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
  • Antti Saraste
    Heart Center, Turku University Hospital, University of Turku, Turku, Finland.
  • Riku Klén
    Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
  • Tanja Kero
    Department of Surgical Sciences, Nuclear Medicine & PET, Uppsala University, Uppsala, Sweden. tanja.kero@uu.se.
  • Takeru Nabeta
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Jeroen J Bax
    Departments of Cardiology, Heart Lung Centre, Leiden University Medical Center, Leiden, The Netherlands.
  • Ibrahim Danad
    Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
  • Nick S Nurmohamed
    Division of Cardiology, The George Washington University School of Medicine, Washington, DC, USA.
  • Ruurt A Jukema
    Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
  • Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
  • Teemu Maaniitty
    Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine, and PET, Turku University Hospital, Turku, Finland.