Noninvasive identification of HER2 status by integrating multiparametric MRI-based radiomics model with the vesical imaging-reporting and data system (VI-RADS) score in bladder urothelial carcinoma.

Journal: Abdominal radiology (New York)
Published Date: Jan 9, 2025

Abstract

PURPOSE: HER2 expression is crucial for the application of HER2-targeted antibody-drug conjugates. This study aims to construct a predictive model by integrating multiparametric magnetic resonance imaging (mpMRI) based multimodal radiomics and the Vesical Imaging-Reporting and Data System (VI-RADS) score for noninvasive identification of HER2 status in bladder urothelial carcinoma (BUC).

Authors

  • Cheng Luo
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
  • Shurong Li
    Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
  • Yichao Han
    First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Jian Ling
    First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Xuanling Wu
    First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Lingwu Chen
    First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Daohu Wang
    Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Junxing Chen
    First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. chenjunx@mail.sysu.edu.cn.

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