Plasma Lyso-PE 22:6 and Lyso-PE 20:4 are associated with development of mild to moderate depression revealed by metabolomics: a pilot study.

Journal: BMC psychiatry
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Mild to moderate depression (MMD), as an early stage of depression, has a high incidence and may progress to severe depression, even leading to suicide. The lack of effective screening and treatment is due to the unknown metabolic changes and processes in patients with MMD. Here, we performed metabolite profiling to investigate the key metabolites associated with MMD in plasma.

Authors

  • Jingbo Yu
    Science&Technology Innovation Center/National Key Laboratory Cultivation Base of Chinese Medicinal Powders & Innovative Medicinal Jiontly Established by Province and Ministry, Hunan Key Laboratory of Traditional Chinses Medicine (TCM) Prevention & Treatment of Depression Disease, Hunan University of Chinese Medicine, Xueshi Road 300, Hanpu Science and Education Park, Yuelu Distirct, Changsha, 410208, China.
  • Haixia He
    The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, 410007, China.
  • Xianyang Chen
    BaoFeng Key Laboratory of Genetics and Metabolism, Beijing, People's Republic of China.
  • Yue Han
  • Yige Song
    Institute for Brain Research, Wuhan Center of Brain Science, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Lei Wang
    Department of Nursing, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Hongqing Zhao
    Science&Technology Innovation Center/National Key Laboratory Cultivation Base of Chinese Medicinal Powders & Innovative Medicinal Jiontly Established by Province and Ministry, Hunan Key Laboratory of Traditional Chinses Medicine (TCM) Prevention & Treatment of Depression Disease, Hunan University of Chinese Medicine, Xueshi Road 300, Hanpu Science and Education Park, Yuelu Distirct, Changsha, 410208, China.
  • Yuhong Wang
    Wuhan Institute for Food and Cosmetic Control, Wuhan 430014, China.

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