Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition.

Journal: Journal of translational medicine
Published Date:

Abstract

BACKGROUND: Pancreatic cancer (PC) represents a highly heterogeneous malignancy with poor prognosis, where precise molecular subtyping facilitates comprehensive understanding of disease progression.

Authors

  • Jiachen Ge
    Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, People's Republic of China.
  • Jianping Cai
    College of Computer Science and Big Data, Fuzhou University, Fuzhou, 350000, China.
  • Gaolei Zhang
    Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, People's Republic of China.
  • Deyu Li
    School of Computer and Information Technology, Shanxi University, Taiyuan, Shanxi 030006, China; Key Laboratory of Computational Intelligence and Chinese Information Processing of Ministry of Education, Taiyuan, Shanxi 030006, China.
  • Lianyuan Tao
    Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, People's Republic of China. tly2007tly@hotmail.com.