Accumulating evidence has demonstrated that biological processes associated with liquid-liquid phase separation (LLPS) play a critical role in cancer development. However, the effect of LLPS on hepatocellular carcinoma (HCC) remains largely unknown. ...
Investigations on epithelial-mesenchymal transition (EMT) events occurring on circulating tumor cells (CTCs) are poised to significantly advance nanoliquid biopsy methodologies. This study presented a colorimetric multiplex lateral flow immunoassay s...
The high heterogeneity of colorectal cancer (CRC) complicates accurate prognosis prediction. Hypoxia can affect cell death mechanisms, leading to resistance to many antitumor therapies and potentially causing relapse. Programmed cell death (PCD) form...
Lactylation is a post-translational modification that can influence the onset and progression of various diseases.However, its role in Idiopathic Pulmonary Fibrosis (IPF) has not been systematically investigated. Single-cell sequencing and bulk RNA s...
Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics analysis, ...
Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor that lacks reliable biological markers for diagnosis and prognostic monitoring. Currently, the differentially expressed genes between paired adjacent normal tissues and ccRCC tum...
BACKGROUND: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Ala...
BACKGROUND: The importance of epithelial‒mesenchymal transition (EMT) in tumour invasion and metastasis in high-grade serous ovarian cancer (HGSOC) has been highlighted in numerous studies, but genetic biomarkers for predicting EMT in HGSOC are still...
The intrinsic complexity of biological processes often hides the role of dynamic microenvironmental cues in the development of pathological states. Microphysiological systems (MPSs) are emerging technological platforms that model dynamics of tissue-...
ETHNOPHARMACOLOGICAL RELEVANCE: Erzhi Pill (EZP), a traditional Chinese medicine used for various cancers, exhibits antitumor potential, though its role and mechanisms in Triple-Negative Breast Cancer (TNBC) remain unclear.
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