Peripheral HLA-DRCD141 Classical Monocytes Predict Relapse Risk and Worsening in Multiple Sclerosis.

Journal: Neurology(R) neuroimmunology & neuroinflammation
Published Date: Jul 3, 2025

Abstract

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS characterized by a heterogeneous disease trajectory, highlighting the need for biomarkers to predict disease activity. Current disease-monitoring tools primarily reflect existing disease damage rather than impending activity. Peripheral blood mononuclear cells (PBMCs) are an ideal source of potential biomarkers due to their accessibility and their known role in MS pathology. Among PBMCs, myeloid cells are key players in MS pathogenic processes, yet they have not been as extensively studied than lymphocytes. The objective of our study was to identify indicators of MS disease activity through immune profiling.

Authors

  • Karine Thai
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Rose-Marie Rebillard
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Wendy Klement
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Othmane Ayoub
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Olivier Tastet
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada.
  • Skander Ben Ahmed
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Bettina Zierfuss
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Camille Grasmuck
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Fiona Tea
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Lyne Bourbonniere
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Clara Margarido
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Chloé Juliette Hoornaert
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Francis Carrier
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Elizabeth Gowing
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Mathieu Dubé
    Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada; and.
  • Stephanie Zandee
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Marc Girard
    Multiple Sclerosis Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
  • Pierre Duquette
    Multiple Sclerosis Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
  • Boaz Lahav
    Multiple Sclerosis Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
  • Nathalie Arbour
    Department of Neuroscience, Université de Montréal, Montréal, Canada.
  • Catherine Larochelle
    Department of Neurosciences, University of Montreal, Montréal, QC, Canada.
  • Alexandre Prat
    Centre de Recherche du Centre Hospitalier de l'Universite de Montreal, University of Montreal, Montreal, QC H2X 0A9, Canada.

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