USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma.

Journal: Journal of translational medicine
Published Date:

Abstract

BACKGROUND: The role of post-translational modifications(PTMs) in PD-L1-mediated immune resistance and melanoma progression remains poorly understood.

Authors

  • Jiaheng Xie
    Department of Management Information Systems, University of Arizona, Tucson, AZ, USA.
  • Pengpeng Zhang
    Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA; Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA. Electronic address: zhangp@mskcc.org.
  • Yuankun Liu
    Department of Neurosurgery, The Afliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. wxrmyylyk@stu.njmu.edu.cn.
  • Dan Wu
    Xi'an Aerospace Propulsion Institute, Xi'an 710049, China.
  • Xueqi Ou
    Department of Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, P. R. China.
  • Ming Wang
    Brain center, Zhejiang Hospital, Hangzhou, China.
  • Wei Yan
    State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: yanwei@njau.edu.cn.
  • Jianlan Liu
    Department of Plastic and Burns Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Jian Tang
    Department of Decision Sciences HEC, Université de Montréal, Montreal, Québec, Canada.
  • Tianyi Ni
    Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Chenfeng Ma
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu, China.
  • Qikai Tang
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu, China.
  • Songyun Zhao
    Department of Neurosurgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
  • Min Qi
    Zhejiang Key Laboratory of Excited-State Energy Conversion and Energy Storage, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.