Phenotypic clustering analysis of patients rejected for mitral valve interventions: implications for future transcatheter technologies.

Journal: European heart journal. Cardiovascular Imaging
Published Date:

Abstract

AIMS: Although several treatment options are available for patients with severe mitral regurgitation (MR), a significant proportion of patients remain ineligible for any mitral valve (MV) intervention. We aimed to analyse the phenotypic characteristics of surgical high-risk patients ineligible for MV interventions using an unsupervised phenotypic clustering approach.

Authors

  • Sebastian Ludwig
    Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
  • Augustin Coisne
    Lille University, Inserm U1011- EGID, Lille, France; Department of Clinical Physiology and Echocardiography, Heart Valve Clinic, Lille University Hospital, Lille, France; Cardiovascular Research Foundation, New York, New York.
  • Kenza Hamzi
    MIRACL.ai Laboratory, Multimodality Imaging for Research and Analysis Core Laboratory and Artificial Intelligence, University Hospital of Lariboisiere (AP-HP), Paris, France.
  • Walid Ben Ali
    Structural Heart Intervention Program, Montreal Heart Institute, Montreal, Quebec, Canada.
  • Andrea Scotti
    Division of Cardiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
  • Benedikt Koell
    Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
  • Alison Duncan
    Royal Brompton Hospital, London, UK.
  • Raj Makkar
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
  • Mariama Akodad
    From the Department of Cardiology (T.P., K.H., T.G., A.L., E.G., A.U., J.G.D., P.H.), MIRACL.ai (Multimodality Imaging for Research and Analysis Core Laboratory: and Artificial Intelligence) (T.P., S.T., K.H., T.G., A.L., E.G., A.U., J.G.D., P.H.), Inserm MASCOT-UMRS 942 (T.P., K.H., T.A.S., T.G., A.L., E.G., A.U., J.G.D., P.H.), and Department of Radiology (T.P., V.B., L.H., T.G.), Université Paris Cité, University Hospital of Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France; Cardiovascular Magnetic Resonance Laboratory (T.P., T.H., T.U., F.S., S.C., P.G., J.G.) and Cardiac Computed Tomography Laboratory (T.P., T.H., T.L., B.C., T.U., F.S., S.C., H.B., A.N., M.A., P.G., J.G.), Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Ramsay Santé, 6 Avenue du Noyer Lambert, 91300 Massy, France; Scientific Partnerships, Siemens Healthcare France, Saint-Denis, France (S.T.); Department of Cardiology, Hôpital Universitaire de Bruxelles-Hôpital Erasme, Brussels, Belgium (A.U.); and Department of Cardiovascular Imaging, American Hospital of Paris, Neuilly, France (O.V., M.S.).
  • Sabine Bleiziffer
    Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center Northrhine-Westphalia, Georgstr 11, 32545 Bad Oeynhausen, Germany.
  • Georg Nickenig
    Department of Internal Medicine II, Heart Center University Hospital Bonn Bonn Germany.
  • Tsuyoshi Kaneko
    Heart and Vascular Center, Brigham and Women's Hospital, Boston, MA, USA.
  • Hendrik Ruge
    Department of Cardiovascular Surgery, German Heart Center Munich, Munich, Germany.
  • Matti Adam
    Department of Cardiology, Heart Center Cologne, University of Cologne, Faculty of Medicine and University Hospital, Kerpener Straße 62, 50937 Cologne, Germany.
  • Lars Sondergaard
    Department of Cardiology, Heart Centre, Rigshospitalet, Copenhagen, Denmark.
  • Gry Dahle
    Department of Cardiothoracic and Cardiovascular Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Maurizio Taramasso
    HerzZentrum Hirslanden, Zurich, Switzerland.
  • Thomas Walther
    Department of Cardiothoracic Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Joerg Kempfert
    Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Berlin, Germany.
  • Jean-François Obadia
    Department of Cardiac Surgery, Louis Pradel Cardiologic Hospital, Lyon, France.
  • Omar Chehab
    Université Paris-Saclay, Inria, CEA, Palaiseau, France.
  • Gilbert H L Tang
    Mount Sinai Health System, New York, New York, USA. Electronic address: gilbert.tang@mountsinai.org.
  • Sachin Goel
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
  • Neil Fam
    Structural Heart Program, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Paolo Denti
    Division of Clinical Pharmacology, Department of Medicine, University of Cape, Cape Town, South Africa.
  • Fabien Praz
    Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Ralph Stephan von Bardeleben
    Heart Valve Center, Heart and Vascular Center, Universitätsmedizin Mainz, Mainz, Germany.
  • Jörg Hausleiter
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
  • Azeem Latib
    Division of Cardiology, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
  • Lenard Conradi
    Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
  • Thomas Modine
    Service Médico-Chirurgical, Valvulopathies-Chirurgie Cardiaque-Cardiologie Interventionelle Structurelle, Hôpital Cardiologique de Haut Lévèque, CHU Bordeaux, France. Electronic address: thomasmodine@gmail.com.
  • Théo Pezel
    Department of Cardiology, University Hospital of Lariboisiere, Université Paris-Cité, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, France.
  • Juan F Granada
    Cardiovascular Research Foundation, Columbia University Medical Center, New York, New York.