METS-VF as a novel predictor of gallstones in U.S. adults: a cross-sectional analysis (NHANES 2017-2020).

Journal: BMC gastroenterology
Published Date: Jul 31, 2025

Abstract

BACKGROUND AND AIMS: Obesity is a well-established risk factor for gallstone formation, but traditional anthropometric measures (e.g., BMI, waist circumference) inadequately assess metabolically active visceral adiposity. The novel Metabolic Score for Visceral Fat (METS-VF) may better capture obesity-related metabolic dysfunction. We aimed to investigate the association between METS-VF and gallstone prevalence and compare its predictive performance against conventional obesity indices (WC, LAP, VAI) in a U.S. national cohort.

Authors

  • Hui Wang
    Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Longlong Li
    College of Mechanical & Electronic Engineering, Northwest A&F University, Shaanxi, 712100, P.R. China; College of Information Engineering, Shaanxi Polytechnic Institute, Shaanxi, 712000, P.R. China.
  • Yi Yang
    Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Siyu Tao
    Department of Laboratory Medicine, Daping Hospital, Army Medical Center of PLA, Chongqing, China, 400042. 15213227714@163.com.
  • Yuan Li
    NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.
  • Hangyu Li
  • Heshan Chen
    College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, 610075, China.
  • Ping Wu

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