Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma.

Journal: Journal for immunotherapy of cancer
Published Date: Jul 31, 2025

Abstract

BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited response. Mitochondrial dysfunction plays a crucial role in tumor development and immune evasion, but its regulatory mechanisms in LUAD immune microenvironment remain unclear.

Authors

  • Pengpeng Zhang
    Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA; Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA. Electronic address: zhangp@mskcc.org.
  • Mengzhe Zhang
    Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, ErQi District, Zhengzhou, Henan, China.
  • Jianlan Liu
    Department of Plastic and Burns Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Zhaokai Zhou
    Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Lianmin Zhang
    Department of Lung Cancer, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Peng Luo
    Institute of Forest Resource Information Techniques, Chinese Academy of Forestry, Beijing 100091, PR China.
  • Zhenfa Zhang
    Department of Lung Cancer, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

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