ODIASP: An Open-Source Software for Automated SMI Determination-Application to an Inpatient Population.

Journal: Journal of cachexia, sarcopenia and muscle
Published Date: Aug 1, 2025

Abstract

BACKGROUND: The diagnosis of malnutrition has evolved with the GLIM recommendations, which advocate for integrating phenotypic criteria, including muscle mass measurement. The GLIM framework specifically suggests using skeletal muscle index (SMI) assessed via CT scan at the third lumbar level (L3) as a first-line approach. However, manual segmentation of muscle from CT images is often time-consuming and infrequently performed in clinical practice. This study is aimed at developing and validating an open-access, simple software tool called ODIASP for automated SMI determination.

Authors

  • Katia Charrière
    IMT Atlantique, Département ITI, Technopôle Brest-Iroise, CS 83818, Brest F-29200, France; Inserm, UMR 1101, 22 avenue Camille-Desmoulins, Brest F-29200, France.
  • Antoine Ragusa
    Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France.
  • Béatrice Genoux
    Public Health Department, Univ. Grenoble Alpes, Clinical Investigation Center-Technological Innovation, INSERM CIC1406, CHU Grenoble Alpes, Grenoble, France.
  • Antoine Vilotitch
    CHU Grenoble Alpes, Cellule d'ingénierie des données, Grenoble, France.
  • Svetlana Artemova
    Public Health Department, Clinical Investigation Center-Technological, Innovation, INSERM CIC1406, CHU Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.
  • Charlène Dumont
    Public Health Department, Univ. Grenoble Alpes, Clinical Investigation Center-Technological Innovation, INSERM CIC1406, CHU Grenoble Alpes, Grenoble, France.
  • Paul-Antoine Beaudoin
    Public Health Department, Univ. Grenoble Alpes, Clinical Investigation Center-Technological Innovation, INSERM CIC1406, CHU Grenoble Alpes, Grenoble, France.
  • Pierre-Ephrem Madiot
    Digital Services Management, CHU Grenoble Alpes, Grenoble, France.
  • Gilbert R Ferretti
    Pôle Imagerie, Centre Hospitalier Universitaire de Grenoble, La Tronche, France.
  • Ivan Bricault
    Univ. Grenoble Alpes, INSERM U1209, IAB, CHU Grenoble Alpes, Service de radiologie diagnostique et interventionnelle, Grenoble, France.
  • Eric Fontaine
    Department of Endocrinology, Diabetology and Nutrition, INSERM U1055, LBFA, CHU Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.
  • Jean-Luc Bosson
    Clinical Investigation Center, Grenoble University Hospital, Grenoble, France.
  • Alexandre Moreau-Gaudry
    Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, 38000, Grenoble, France.
  • Joris Giai
    Clinical Investigation Center, Grenoble University Hospital, Grenoble, France.
  • Cécile Bétry
    Centre Intégré de l'Obésité Rhône-Alpes, Fédération Hospitalo-Universitaire DO-iT, Department of Endocrinology and Nutrition, Groupement Hospitalier Sud, Hospices Civils de Lyon, Lyon, France.

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