Explainable machine learning model for predicting internal mammary node metastasis in breast cancer: Multi-method development and cross-cohort validation.

Journal: Breast (Edinburgh, Scotland)
Published Date:

Abstract

BACKGROUND: This study developed an explainable machine learning model for baseline internal mammary lymph node metastasis (IMNM) in breast cancer patients.

Authors

  • Yirong Xiang
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, China.
  • Jian Tie
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, China.
  • Siyuan Zhang
    Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 11, Singapore, 119228, Singapore.
  • Chen Shi
    Sino-Dutch R&D Centre for Future Wastewater Treatment Technologies, Key Laboratory of Urban Stormwater System and Water Environment, Beijing University of Civil Engineering and Architecture Beijing 100044 China xdhao@hotmail.com.
  • Changkuo Guo
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, China.
  • Yushuo Peng
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, China.
  • Zhaoqing Fan
    Breast Center, Peking University Cancer Hospital and Institute, China. Electronic address: zhqfan@bjmu.edu.cn.
  • Weihu Wang
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, China. Electronic address: wangweihu88@163.com.