AI-powered prostate cancer detection: a multi-centre, multi-scanner validation study.

Journal: European radiology
Published Date:

Abstract

OBJECTIVES: Multi-centre, multi-vendor validation of artificial intelligence (AI) software to detect clinically significant prostate cancer (PCa) using multiparametric magnetic resonance imaging (MRI) is lacking. We compared a new AI solution, validated on a separate dataset from different UK hospitals, to the original multidisciplinary team (MDT)-supported radiologist's interpretations.

Authors

  • Francesco Giganti
    Department of Radiology, University College London Hospital, London, UK.
  • Nádia Moreira da Silva
    From the Translational and Clinical Research Institute (N.S.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (N.S., Y.W., N.M.d.S., P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne; NIHR University College London Hospitals Biomedical Research Centre (Y.W., A.M., A.W.M., J.d.T., S.B.V., G.P.W., J.S.D., P.N.T.), UCL Institute of Neurology, Queen Square; Centre for Medical Image Computing (S.B.V.), University College London; Epilepsy Society MRI Unit (S.B.V., G.P.W., J.S.D), Chalfont St Peter, UK; and Department of Medicine (G.P.W.,), Division of Neurology, Queen's University, Kingston, Ontario, Canada.
  • Michael Yeung
    Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, United Kingdom. Electronic address: mjyy2@cam.ac.uk.
  • Lucy Davies
    Lucida Medical Ltd, Cambridge, UK.
  • Amy Frary
    Lucida Medical Ltd, Cambridge, UK.
  • Mirjana Ferrer Rodriguez
    Lucida Medical Ltd, Cambridge, UK.
  • Nikita Sushentsev
    Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, UK.
  • Nicholas Ashley
    Lucida Medical Ltd, Cambridge, UK.
  • Adrian Andreou
    Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
  • Alison Bradley
  • Chris Wilson
    Lucida Medical Ltd, Cambridge, UK.
  • Giles Maskell
    Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK.
  • Giorgio Brembilla
    Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Iztok Caglic
    Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, UK.
  • Jakub Suchánek
    Fabrica AI Corp., Delaware City, DE, USA.
  • Jobie Budd
    London Centre for Nanotechnology, University College London, London, UK.
  • Zobair Arya
    Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.
  • Jonathan Aning
    North Bristol NHS Trust, Bristol, UK.
  • John Hayes
    East and North Herts NHS Trust, Stevenage, UK.
  • Mark De Bono
    Mid and South Essex NHS Foundation Trust, Southend, UK.
  • Nikhil Vasdev
    Hertfordshire and Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, Hertfordshire, UK. nikhilvasdev@doctors.org.uk.
  • Nimalan Sanmugalingam
    Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, UK.
  • Paul Burn
    Somerset NHS Foundation Trust, Taunton, UK.
  • Raj Persad
    North Bristol, NHS Trust, Bristol, United Kingdom.
  • Ramona Woitek
    Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK; Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna 1090, Austria. Electronic address: rw585@cam.ac.uk.
  • Richard Hindley
    Department of Urology, Hampshire Hospitals, Basingstoke, UK.
  • Sidath Liyanage
    Department of Software Engineering, Faculty of Computing & Technology, University of Kelaniya, Sri Lanka.
  • Sophie Squire
    Hampshire Hospitals NHS Foundation Trust, Winchester, UK.
  • Tristan Barrett
    Department of Radiology, University of Cambridge, Cambridge, UK.
  • Steffi Barwick
    Lucida Medical Ltd, Cambridge, UK.
  • Mark Hinton
    Lucida Medical Ltd, Cambridge, UK.
  • Anwar R Padhani
    From the Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, England (A.R.P.); and Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.T.).
  • Antony Rix
    Lucida Medical Ltd, Cambridge, UK.
  • Aarti Shah
    Hampshire Hospitals NHS Foundation Trust, Winchester, UK.
  • Evis Sala
    Department of Radiology and Cancer Research UK Cambridge Centre, University of Cambridge, Box 218, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, England.