Metabolic phenotyping combined with transcriptomics metadata fortifies the diagnosis of early-stage Hepatocellular carcinoma.

Journal: Journal of advanced research
Published Date: Sep 6, 2024

Abstract

INTRODUCTION: The low sensitivity of alpha-fetoprotein (AFP) renders it unsuitable as a stand-alone marker for early hepatocellular carcinoma (eHCC) surveillance. Therefore, additional blood-based biomarkers with enhanced sensitivities are required.

Authors

  • Sun Jo Kim
    Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea; College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
  • Cheol Woon Jung
    College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  • Nguyen Hoang Anh
    School of Medicine, Vietnam National University, Ho Chi Minh 70000, Vietnam.
  • Young Cheol Yoon
    1 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Nguyen Phuoc Long
    Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, 47392, Republic of Korea.
  • Soon-Sun Hong
    Department of Drug Development, College of Medicine, Inha University, Incheon 22212, Korea.
  • Eun Ju Cho
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Sung Won Kwon
    College of Pharmacy, Seoul National University, Seoul 08826, Korea.

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