Association between albumin-corrected anion gap and delirium in acute pancreatitis: insights from the MIMIC-IV database.

Journal: BMC gastroenterology
Published Date: Aug 5, 2025

Abstract

BACKGROUND: Delirium frequently occurs as a severe complication among patients with acute pancreatitis (AP), contributing to extended hospital stays, higher mortality rates, and lasting cognitive deficits. The pathogenesis of delirium in this setting is strongly influenced by metabolic abnormalities, including disturbances in electrolyte balance and widespread inflammation. Although the albumin-corrected anion gap (ACAG) is a recognized indicator of metabolic dysfunction, its relevance to delirium in AP patients has not been adequately investigated.

Authors

  • Yuanshuo Ge
    Department of General Surgery, General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area), Shenyang, China; Jinzhou Medical University, Jinzhou, Liaoning Province, China.
  • Youran Ma
    Department of General Surgery, General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area), Shenyang, China.
  • Peng Lv
    School of Computer and Communication Engineering, University of Science and Technology Beijing (USTB), No. 30 Xueyuan Road, Haidian District, Beijing 100083, China.
  • Junhao Ren
    Department of General Surgery, General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area), Shenyang, China.
  • Zhe Wang
    Department of Pathology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
  • Cheng Zhang
    College of Forestry, Jiangxi Agricultural University, Nanchang, Jiangxi Province, China.

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