Unraveling Microstructural and Macrostructural Brain Age Dynamics in Multiple Sclerosis.

Journal: Neurology(R) neuroimmunology & neuroinflammation
Published Date:

Abstract

BACKGROUND AND OBJECTIVES: In multiple sclerosis (MS), neurodegeneration results from the interplay between disease-specific pathology and normal aging. Conventional MRI captures morphologic changes in neurodegeneration, while quantitative MRI (qMRI) provides biophysical measures of microstructural alterations. Combining these modalities may reveal how aging and pathology interact and contribute to disability progression in people with MS.

Authors

  • Xinjie Chen
    Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Wuhua District, Kunming, Yunnan Province, China.
  • Po-Jui Lu
    Translational Imaging in Neurology Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland; Neurologic Clinic and Policlinic, Departments of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Mario Ocampo-Pineda
    Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk) Basel, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.
  • Alessandro Cagol
    From the Queen Square Multiple Sclerosis Centre (G.P., F.P., J.C., B.K., O.A.-M., S.A.-A., A. Bianchi, W.J.B., R. Christensen, E.C., S. Collorone, M.A.F., Y.H., A.H., S. Mohamud, R.N., A.T.T., J.W., C.Y., O.C., F.B.), Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, United Kingdom; MS Center Amsterdam (G.P., H.V., F.B.), Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Departments of Advanced Biomedical Sciences and Electrical Engineering and Information Technology (G.P., A. Brunetti, S. Cocozza), University of Naples "Federico II," Italy; Centre for Medical Image Computing (F.P., B.K., F.B.), Department of Medical Physics and Biomedical Engineering, University College London, United Kingdom; E-Health Center (F.P.), Universitat Oberta de Catalunya, Barcelona, Spain; Institute of Neuroradiology (B.B., C.L.), St. Josef Hospital, Ruhr-University Bochum, Germany; Department of Advanced Medical and Surgical Sciences (A. Bisecco, A.G.), University of Campania "Luigi Vanvitelli," Naples, Italy; Translational Imaging in Neurology (ThINK) Basel (A.C., C. Granziera), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel, University of Basel; Neurologic Clinic and Policlinic (A.C., C. Granziera, J.K.), MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Switzerland; Department of Neurosciences, Biomedicine and Movement Sciences (M. Calabrese, M. Castellaro), University of Verona; Department of Information Engineering (M. Castellaro), University of Padova; Department of Medicine, Surgery and Neuroscience (R. Cortese, N.D.S.), University of Siena, Italy; Department of Neurology (C.E., D.P.), Medical University of Graz, Austria; Neuroimaging Research Unit (M.F., M.A.R., P.V.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Neurology Unit, Neurorehabilitation Unit, Neurophysiology Service, IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (M.F., M.A.R., P.V.), Milan; Department of Neurosciences (C. Gasperini, S.R.), San Camillo-Forlanini Hospital, Rome, Italy; Department of Neurology (G.G.-E., S.G.), Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Germany; Department of Neurology (H.F.F.H., E.A.H., G.O.N.), Oslo University Hospital; Institute of Clinical Medicine (H.F.F.H., E.A.H., G.O.N.), and Department of Psychology (E.A.H.), University of Oslo, Norway; Neuroimmunology and Multiple Sclerosis Unit Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM) (S.L., E.M.-H.), Hospital Clinic Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Su, Barcelona, Spain; Department of Neurology (C.L.), St. Josef Hospital, Ruhr-University Bochum, Germany; Nuffield Department of Clinical Neurosciences (S. Messina, J.P.), University of Oxford, United Kingdom; Department of Molecular Medicine and Medical Biotechnology (M.M.), and Department of Neurosciences and Reproductive and Odontostomatological Sciences (M.P.), University of Naples "Federico II"; Department of Human Neurosciences (M.P.), Sapienza University of Rome, Italy; Section of Neuroradiology (A.R.), Department of Radiology, and Centre d'Esclerosi Múltiple de Catalunya (Cemcat) (J.S.-G.), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; MS Center Amsterdam (E.M.M.S.), Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Department of Neurology and Center of Clinical Neuroscience (T.U.), and Department of Radiology (M.V.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; MS Center Amsterdam (M.M.S.), Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Centre for Medical Image Computing (J.H.C.), Department of Computer Science, and Dementia Research Centre (J.H.C., F.B.), UCL Queen Square Institute of Neurology, University College London, United Kingdom.
  • Sabine Anna Schaedelin
    Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk) Basel, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.
  • Esther Ruberte
    Medical Image Analysis Center (MIAC), Basel, Switzerland.
  • Matthias Weigel
    Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk) Basel, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.
  • Federico Spagnolo
    Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk) Basel, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.
  • Pascal Benkert
    Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Switzerland.
  • Johanna Maria Lieb
    Division of Diagnostic and Interventional Neuroradiology, Clinic for Radiology and Nuclear Medicine, University Hospital Basel and University of Basel, Switzerland.
  • David Leppert
    Neurologic Clinic and Policlinic, Multiple Sclerosis (MS) Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Clinical Research and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Özgür Yaldizli
    Department of Neurology, University Hospital Basel, Switzerland.
  • Johanna Oechtering
    Neurologic Clinic and Policlinic, Multiple Sclerosis (MS) Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Clinical Research and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Marcus D'Souza
    Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Bettina Fischer-Barnicol
    Department of Neurology, University Hospital Basel, Switzerland.
  • Tobias J Derfuss
    Department of Neurology, University Hospital Basel, Switzerland.
  • Clara Ekerdt
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Willeke M Menks
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Kwok-Shing Chan
    Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.
  • Marcel Zwiers
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Andrew Chan
    Univeristy Clinic for Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Robert Hoepner
    Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland.
  • Franca Wagner
    d University Department of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital , Bern , Switzerland.
  • Caroline Pot
    Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
  • Renaud A Du Pasquier
    Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
  • Sebastian Finkener
    Department of Neurology, Cantonal Hospital Aarau, Switzerland.
  • Michael Diepers
    Department of Neuroradiology, Cantonal Hospital Aarau, Switzerland.
  • Claire Bridel
    Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, Switzerland.
  • Patrice H Lalive
    Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, Switzerland.
  • Marjolaine Uginet
    Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, Switzerland.
  • Claudio Gobbi
    Neurology Department, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.
  • Chiara Zecca
    Neurology Department, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.
  • Emanuele Pravatà
    Neuroradiology Department, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Lugano, Switzerland.
  • Giulio Disanto
    Neurology Department, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.
  • Patrick Roth
    Emergency and Trauma Imaging, Department of Radiology, University of Miami - Miller School of Medicine, Jackson Memorial Hospital - Ryder Trauma Center, Miami, USA.
  • Jochen Vehoff
    Department of Neurology, Cantonal Hospital St. Gallen, Switzerland.
  • Stefanie Mueller
    Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riβ, Germany.
  • Olaf Chan-Hi Kim
    Clinic for Radiology, Cantonal Hospital St. Gallen, Switzerland.
  • Ludwig Kappos
    Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Jens Kuhle
    Neurologic Clinic and Policlinic, Multiple Sclerosis (MS) Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Clinical Research and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Lester Melie-Garcia
    Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk) Basel, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.
  • José P Marques
    Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.
  • Cristina Granziera
    Translational Imaging in Neurology Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland; Neurologic Clinic and Policlinic, Departments of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.