Oral and Gut Dysbiosis in Migraine: Oral Microbial Signatures as Biomarkers of Migraine.

Journal: Neurology(R) neuroimmunology & neuroinflammation
Published Date: Jun 30, 2025

Abstract

BACKGROUND AND OBJECTIVES: Emerging evidence suggests that oral health conditions may exacerbate migraine, and saliva is a potential source of biomarkers for migraine. The 3-way interaction of the oral-gut-brain axis has been implicated in several neurologic disorders, but has rarely been studied in migraine. This study examined the oral and gut microbiomes simultaneously and identified several key oral microbes that may influence migraine.

Authors

  • Soomi Cho
    Department of Neurology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Yeonjae Jung
    CJ Bioscience Inc., Seoul, Republic of Korea; and.
  • Hyun-Seok Oh
    CJ Bioscience Inc., Seoul, Republic of Korea; and.
  • Jungyon Yum
    Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Seungwon Song
    Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • JaeWook Jeong
    Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Woo-Seok Ha
    Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kyung Min Kim
    Hewlett Packard Labs, Palo Alto, CA, 94304, USA.
  • Won-Joo Kim
    Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Min Kyung Chu
    Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

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