AIMC Topic: Migraine Disorders
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Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.
The journal of headache and pain
Jun 23, 2025
BACKGROUND: Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas...
Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.
The journal of headache and pain
Jun 12, 2025
BACKGROUND: Accumulating evidence suggests that migraine patients present abnormal brain responses to salient sensory and emotional stimuli. However, it is still unclear whether this is a generalized or domain-specific phenomenon. Employing a well-va...
Patterns of calcitonin gene-related peptide monoclonal antibody use in people with migraine: Results of the OVERCOME (US) study.
Cephalalgia : an international journal of headache
Jun 12, 2025
BackgroundUnderstanding characteristics and reasons associated with using calcitonin gene-related peptide monoclonal antibodies (CGRP mAb) for migraine prevention may help clinicians individualize treatment plans and achieve better patient outcomes.M...
Unveiling new insights into migraine risk stratification using machine learning models of adjustable risk factors.
The journal of headache and pain
May 6, 2025
BACKGROUND: Migraine ranks as the second-leading cause of global neurological disability, affecting approximately 1.1 billion individuals worldwide with severe quality-of-life impairments. Although adjustable risk factors-including environmental expo...
Prediction of new-onset migraine using clinical-genotypic data from the HUNT Study: a machine learning analysis.
The journal of headache and pain
Apr 7, 2025
BACKGROUND: Migraine is associated with a range of symptoms and comorbid disorders and has a strong genetic basis, but the currently identified risk loci only explain a small portion of the heritability, often termed the "missing heritability". We ai...
Artificial neural networks applied to somatosensory evoked potentials for migraine classification.
The journal of headache and pain
Apr 4, 2025
BACKGROUND: Finding a biomarker to diagnose migraine remains a significant challenge in the headache field. Migraine patients exhibit dynamic and recurrent alterations in the brainstem-thalamo-cortical loop, including reduced thalamocortical activity...
Machine learning models and classification algorithms in the diagnosis of vestibular migraine: A systematic review and meta-analysis.
Headache
Mar 13, 2025
OBJECTIVES: To perform a systematic review and meta-analysis to evaluate the effectiveness of machine learning (ML) algorithms in the diagnosis of vestibular migraine.
Artificial Intelligence and Predictive Modeling in the Management and Treatment of Episodic Migraine.
Current pain and headache reports
Feb 26, 2025
PURPOSE OF REVIEW: Artificial intelligence (AI) has impacted different aspects of headache medicine, from history taking and diagnosis to drug development. AI has been shown to have predictive modeling in helping diagnose migraine and assist with pat...
Prediction models for treatment response in migraine: a systematic review and meta-analysis.
The journal of headache and pain
Feb 12, 2025
BACKGROUND: Migraine is a complex neurological disorder with significant clinical variability, posing challenges for effective management. Multiple treatments are available for migraine, but individual responses vary widely, making accurate predictio...
Machine learning-driven identification of critical gene programs and key transcription factors in migraine.
The journal of headache and pain
Jan 20, 2025
BACKGROUND: Migraine is a complex neurological disorder characterized by recurrent episodes of severe headaches. Although genetic factors have been implicated, the precise molecular mechanisms, particularly gene expression patterns in migraine-associ...
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