Evaluation of amyloid PET positivity using machine learning on F-FDG PET images.

Journal: Japanese journal of radiology
Published Date: May 2, 2025

Abstract

BACKGROUND: Since the approval of disease-modifying drugs for Alzheimer's disease, the demand for amyloid positron emission tomography (PET) scans, which are crucial for determining treatment eligibility, is expected to increase significantly. We thus investigated the ability of an algorithm to predict amyloid accumulation from F-fluorodeoxyglucose (FDG)-PET images for use in amyloid PET screening.

Authors

  • Takahiro Yamada
    Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osaka, Japan.
  • Yuichi Kimura
    Graduate School of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan. ukimura@ieee.org.
  • Shogo Watanabe
    Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Aya Watanabe
    Graduate School of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan.
  • Misa Honda
    Graduate School of Science and Engineering, Kindai University, Osaka, Japan.
  • Takashi Nagaoka
    Graduate School of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan.
  • Mitsutaka Nemoto
    The University of Tokyo Hospital.
  • Kohei Hanaoka
    Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osaka, Japan.
  • Hayato Kaida
    Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osaka, Japan.
  • Yasuyuki Kojita
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Minoru Yamada
    Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
  • SungWoon Im
    Department of Radiology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
  • Atsushi Kono
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan (T.M., A.K., H.M., H.H., T.M.).
  • Kazunari Ishii
    Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osaka, Japan.

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